Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by copy number variations (CNVs). We observed that 149 hiPSC lines...

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Bibliographic Details
Main Authors: Kanika Kanchan, Kruthika Iyer, Lisa R Yanek, Ivan Carcamo-Orive, Margaret A Taub, Claire Malley, Kristin Baldwin, Lewis C Becker, Ulrich Broeckel, Linzhao Cheng, Chad Cowan, Matteo D'Antonio, Kelly A Frazer, Thomas Quertermous, Gustavo Mostoslavsky, George Murphy, Marlene Rabinovitch, Daniel J Rader, Martin H Steinberg, Eric Topol, Wenli Yang, Joshua W Knowles, Cashell E Jaquish, Ingo Ruczinski, Rasika A Mathias
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Stem Cell Research
Subjects:
hiPSCs
Structural integrity
GWAS, VanillaICE
Oncogenes
Tumor suppressor genes
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120301057

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http://www.sciencedirect.com/science/article/pii/S1873506120301057

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