Bursopentin (BP5) induces G1 phase cell cycle arrest and endoplasmic reticulum stress/mitochondria-mediated caspase-dependent apoptosis in human colon cancer HCT116 cells

Bursopentin (BP5) induces G1 phase cell cycle arrest and endoplasmic reticulum stress/mitochondria-mediated caspase-dependent apoptosis in human colon cancer HCT116 cells

Abstract Background Bursopentin (BP5) is a multifunctional pentapeptide found in the chicken bursa of Fabricius. Recent study indicated that BP5 significantly stimulates expression of p53 protein in colon cancer HCT116 cells. However, the effects and underlying mechanisms of BP5 on HCT116 cell proli...

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Bibliographic Details
Main Authors: Jing Li, Tian-xiang Li, Yao Ma, Yong Zhang, De-yuan Li, Hai-rong Xu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer Cell International
Subjects:
Apoptosis
Endoplasmic reticulum stress
G1 cell cycle arrest
Mitochondrial pathway
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12935-019-0849-3

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http://link.springer.com/article/10.1186/s12935-019-0849-3

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