Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells

Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells

Abstract Background The blood–brain barrier (BBB) plays an important role as a biological barrier by regulating molecular transport between circulating blood and the brain parenchyma. In drug development, the accurate evaluation of BBB permeability is essential to predict not only the efficacy but a...

Full description

Bibliographic Details
Main Authors: Misaki Yamashita, Hiromasa Aoki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Cell differentiation
Endothelial cells
Induced pluripotent stem cells
Transforming growth factor beta
Online Access:http://link.springer.com/article/10.1186/s12987-020-00197-1

Internet

http://link.springer.com/article/10.1186/s12987-020-00197-1

Similar Items