3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low na...

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Bibliographic Details
Main Authors: Josef Köhrle, Ina Lehmphul, Maik Pietzner, Kostja Renko, Eddy Rijntjes, Keith Richards, João Anselmo, Mark Danielsen, Jacqueline Jonklaas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Endocrinology
Subjects:
thyroid hormone
3,5-diiodothyronine
hypothyroidism
metabolome
anti-steatotic action
coffee metabolites
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00787/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00787/full

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