Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Abstract Background The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses and its mechanism of action have not been studied in detail. Methods B...

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Bibliographic Details
Main Authors: Ka-Young Ryu, Hyun-ju Lee, Hanwoong Woo, Ri-Jin Kang, Kyung-Min Han, HyunHee Park, Sang Min Lee, Ju-Young Lee, Yoo Joo Jeong, Hyun-Wook Nam, Youngpyo Nam, Hyang-Sook Hoe
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
LPS
Neuroinflammation
STAT3
AKT
Microglia
Astrocytes
Online Access:http://link.springer.com/article/10.1186/s12974-019-1561-x

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http://link.springer.com/article/10.1186/s12974-019-1561-x

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