The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation

The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation

CD4+ T cell mediated uveitis is conventionally treated with systemic immunosuppressive agents, including corticosteroids and biologics targeting key inflammatory cytokines. However, their long-term utility is limited due to various side effects. Here, we investigated whether DNA methylation inhibito...

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Bibliographic Details
Main Authors: Yanli Zou, Xiao Hu, Lauren P. Schewitz-Bowers, Madeleine Stimpson, Li Miao, Xiaofei Ge, Liu Yang, Yan Li, Paul W. Bible, Xiaofeng Wen, Jing Jing Li, Yizhi Liu, Richard W. J. Lee, Lai Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
uveitis
zebularine
DNA methylation inhibitor
CD4+ T cell
intraocular inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01950/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01950/full

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