Antitumor Effects of PRIMA-1 and PRIMA-1<sup>Met</sup> (APR246) in Hematological Malignancies: Still A Mutant P53-Dependent Affair?

Antitumor Effects of PRIMA-1 and PRIMA-1<sup>Met</sup> (APR246) in Hematological Malignancies: Still A Mutant P53-Dependent Affair?

Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the <i>TP53</i> tumor suppressor gene is a key player for cellular homeostasis. <i>TP53</i> gene is mutated in more than 50% of...

Full description

Bibliographic Details
Main Authors: Paola Menichini, Paola Monti, Andrea Speciale, Giovanna Cutrona, Serena Matis, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
PRIMA-1/APR246
hematological malignancies
mutant P53
CLL
leukemia
Online Access:https://www.mdpi.com/2073-4409/10/1/98

Internet

https://www.mdpi.com/2073-4409/10/1/98

Similar Items