A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss

A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss

Abstract Background Hirudin is a potent thrombin inhibitor but its antithrombotic properties are offset by bleeding side-effects. Because hirudin’s N-terminus must engage thrombin’s active site for effective inhibition, fusing a cleavable peptide at this site may improve hirudin’s risk/benefit ratio...

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Bibliographic Details
Main Authors: William P. Sheffield, Louise J. Eltringham-Smith, Varsha Bhakta
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Biotechnology
Subjects:
Hirudin
Albumin
Thrombin
Factor XI
Thrombosis
Hemorrhage
Online Access:http://link.springer.com/article/10.1186/s12896-018-0431-4

Internet

http://link.springer.com/article/10.1186/s12896-018-0431-4

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