Leptin-deficient mice have altered three-dimensional growth plate histomorphometry

Leptin-deficient mice have altered three-dimensional growth plate histomorphometry

Abstract Background Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development of obesity and type 2 diabetes mellitus, as well as reduced limb bon...

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Bibliographic Details
Main Authors: Jun Hung, Layla Al-Nakkash, Tom L. Broderick, Monica Castro, Jeffrey H. Plochocki
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Obesity
Leptin
Ob/ob mice
Bone
Cartilage
Chondrocytes
Online Access:http://link.springer.com/article/10.1186/s13098-019-0402-5

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http://link.springer.com/article/10.1186/s13098-019-0402-5

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