Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST

Background: Gastrointestinal stromal tumors (GIST) are known to carry oncogenic KIT or PDGFRA mutations, or less commonly SDH or NF1 gene inactivation, with very rare cases harboring mutant BRAF or RAS alleles. Approximately 10% of GISTs are devoid of any of such mutations and are characterized by v...

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Bibliographic Details
Main Authors: Annalisa Astolfi, Valentina Indio, Margherita Nannini, Maristella Saponara, Angela Schipani, Antonio De Leo, Annalisa Altimari, Bruno Vincenzi, Danila Comandini, Giovanni Grignani, Paola Secchiero, Milena Urbini, Maria Abbondanza Pantaleo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
gastrointestinal stromal tumor
GIST
KIT
quadruple-WT
deep sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00504/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00504/full

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