Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as a fingerprint of aflatoxin B(1) exposure. Like...

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Bibliographic Details
Main Authors: Vincent Paget, Mathilde Lechevrel, Véronique André, Jérémie Le Goff, Didier Pottier, Sylvain Billet, Guillaume Garçon, Pirouz Shirali, François Sichel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319594/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319594/?tool=EBI

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