Clonal Heterogeneity Influences the Fate of New Adaptive Mutations

Clonal Heterogeneity Influences the Fate of New Adaptive Mutations

The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid ce...

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Bibliographic Details
Main Authors: Ignacio Vázquez-García, Francisco Salinas, Jing Li, Andrej Fischer, Benjamin Barré, Johan Hallin, Anders Bergström, Elisa Alonso-Perez, Jonas Warringer, Ville Mustonen, Gianni Liti
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
clonal heterogeneity
genetic variation
population dynamics
genome evolution
mutation
adaptation
quantitative traits
drug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313360

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http://www.sciencedirect.com/science/article/pii/S2211124717313360

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