Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation

Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation

Activation of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome cascade has a role in the pathogenesis of ischemia/reperfusion (IR) injury. There is growing evidence indicating cytochrome p450 (CYP450)-derived metabolites of n-3 a...

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Bibliographic Details
Main Authors: Ahmed M. Darwesh, Hedieh Keshavarz-Bahaghighat, K. Lockhart Jamieson, John M. Seubert
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
cardioprotection
ischemia-reperfusion
mitochondria
NLRP3 inflammasome
polyunsaturated fatty acids
soluble epoxide hydrolase
Online Access:https://www.mdpi.com/1422-0067/20/14/3502

Internet

https://www.mdpi.com/1422-0067/20/14/3502

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