Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats

Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats

The α5 subunit-containing gamma-amino butyric acid type A receptors (α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane,...

Full description

Bibliographic Details
Main Authors: Zi-Fang Zhao, Lei Du, Teng Gao, Lin Bao, Yuan Luo, Yi-Qing Yin, Yong-An Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; subarachnoid hemorrhage; Wnt/Frizzled signaling pathway; early brain injury; nuclear factor-κB; M2 type microglia; peroxisome proliferator-activated receptor-γ; inflammatory cytokines; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1029;epage=1036;aulast=Zhao

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1029;epage=1036;aulast=Zhao

Similar Items