Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers

Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers

Lactols and cyclic hemiaminals were directly used in a one-pot organo/organo dual catalytic system induced [2+2+2] tandem reaction for the asymmetric construction of six-membered carbocycles. The enamine-based stereoselective Michael addition of lactols or cyclic hemiaminals to electron-deficient ol...

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Bibliographic Details
Main Authors: Zhi-Long Li, Chao Liu, Rui Tan, Zhi-Ping Tong, Yan-Kai Liu
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Catalysts
Subjects:
asymmetric organocatalysis
tandem reaction
lactol
cyclic hemiaminal
[2+2+2] annulation
spirocyclic oxindole
Online Access:http://www.mdpi.com/2073-4344/6/5/65

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http://www.mdpi.com/2073-4344/6/5/65

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