Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells

Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells

In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS). We examined the effect of angiotensin II on ABCA1 expression i...

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Bibliographic Details
Main Authors: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Toshihiro Kobayashi, Tao Dong, Takuo Yoshimoto, Kazuko Yonezaki, Hiromi Nagata, Hisakazu Iwama, Koji Murao
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
MAPK kinase/ERK1/2
lipotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341821

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http://www.sciencedirect.com/science/article/pii/S0022227520341821

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