Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwe...

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Bibliographic Details
Main Authors: Youming Zhang, Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Martin S. Taylor, Lauren Chessum, Jackie Harrison, Loukia Tsaprouni, Ian M. Adcock, Clare M. Lloyd, William O. Cookson, Miriam F. Moffatt, Charlotte H. Dean
Format: Article
Language:English
Published: The Company of Biologists 2018-01-01
Series:Disease Models & Mechanisms
Subjects:
DPP10
Point mutation
IgE
Airway resistance
Asthma
Online Access:http://dmm.biologists.org/content/11/1/dmm031369

Internet

http://dmm.biologists.org/content/11/1/dmm031369

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