Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions

Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create a significant public health burden. The majority of OFCs are non-syndromic and vary in prevalence by ethnicity. Africans have the lowest prevalence of OFCs (~ 1/2,500), Asians have the highest preval...

Full description

Bibliographic Details
Main Authors: Nandita Mukhopadhyay, Eleanor Feingold, Lina Moreno-Uribe, George Wehby, Luz Consuelo Valencia-Ramirez, Claudia P. Restrepo Muñeton, Carmencita Padilla, Frederic Deleyiannis, Kaare Christensen, Fernando A. Poletta, Ieda M. Orioli, Jacqueline T. Hecht, Carmen J. Buxó, Azeez Butali, Wasiu L. Adeyemo, Alexandre R. Vieira, John R. Shaffer, Jeffrey C. Murray, Seth M. Weinberg, Elizabeth J. Leslie, Mary L. Marazita
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
multiethnic
GWAS
genetic factors in OFC
genetic heterogeneity
family study
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.621482/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.621482/full

Similar Items