Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation

Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation

Abstract Background This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms. Methods Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages was used as an in...

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Bibliographic Details
Main Authors: Jianjun Jiang, Yining Shi, Jiyu Cao, Youjin Lu, Gengyun Sun, Jin Yang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Lipids in Health and Disease
Subjects:
Lipopolysaccharide
J774A.1 cells
THP-1 macrophages
Thioredoxin interacting protein
Acid sphingomyelinase
NOD-like receptor Protein3
Online Access:https://doi.org/10.1186/s12944-021-01446-4

Internet

https://doi.org/10.1186/s12944-021-01446-4

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