Functional Characterisation of Human CYP2C9 Allelic Variants in COS-7 cells

Functional Characterisation of Human CYP2C9 Allelic Variants in COS-7 cells

Variability in activity of CYP2C9, which is involved in the metabolism of approximately 15% of current therapeutic drugs, is an important contributor to interindividual differences in drug response. To evaluate the functional alternations of CYP2C9*2, CYP2C9*3, CYP2C9*8, CYP2C9*11 and CYP2C9*31, ide...

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Bibliographic Details
Main Authors: Huihui eDu, Zhiyun eWei, Yucai eYan, Yuyu eXiong, Xiaoqing eZhang, Lu eShen, Yunfeng eRuan, Xi eWu, Qingqing eXu, Lin eHe, Shengying eQin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Pharmacology
Subjects:
In vitro Models
pharmacokinetics
cytochrome P450
HPLC
Genetic polymorphisms
Chinese han
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00098/full

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