Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands

Members of the tumour necrosis factor (TNF) superfamily OX40L and CD70 and their receptors are costimulating signalling axes critical for adequate T cell activation in humans and mice but characterisation of these molecules in other species including ruminants is lacking. Here we cloned and expresse...

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Bibliographic Details
Main Authors: José Manuel Rojas, Alí Alejo, Jose Miguel Avia, Daniel Rodríguez-Martín, Carolina Sánchez, Antonio Alcamí, Noemí Sevilla, Verónica Martín
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/8/2/333