Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease; however, its etiology remains largely unknown. We previously demonstrated that genetic variants in the MYH6 gene are significantly associated with HLHS. Additionally, induced pluripotent...

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Bibliographic Details
Main Authors: Min-Su Kim, Brandon Fleres, Jerrell Lovett, Melissa Anfinson, Sai Suma K. Samudrala, Lauren J. Kelly, Laura E. Teigen, Matthew Cavanaugh, Maribel Marquez, Aron M. Geurts, John W. Lough, Michael E. Mitchell, Robert H. Fitts, Aoy Tomita-Mitchell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HLHS
hypoplastic left heart syndrome
iPSC-cardiomyocytes
MYH6
contractility
CRISPR/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00440/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00440/full

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