Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation

Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation

Oxidation of LDL is thought to be involved in both initiating and sustaining atherogenesis through the formation of proinflammatory lipids and the covalent modification of LDL particles. Platelet-activating factor (PAF; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent phospholipid mediato...

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Bibliographic Details
Main Authors: Nicolaos Androulakis, Hervé Durand, Ewa Ninio, Demokritos C. Tsoukatos
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Journal of Lipid Research
Subjects:
oxidized phospholipids
platelet-activating factor-acetylhydrolase
platelet-activating factor-transacetylase
mediators of inflammation
atherogenesis
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329394

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http://www.sciencedirect.com/science/article/pii/S0022227520329394

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