The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

Abstract Background Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologically healthy individuals in four age categories (range 20-95y) via mul...

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Bibliographic Details
Main Authors: Alice F. Muggen, Madelon de Jong, Ingrid L. M. Wolvers-Tettero, Martine J. Kallemeijn, Cristina Teodósio, Nikos Darzentas, Ralph Stadhouders, Hanna IJspeert, Mirjam van der Burg, Wilfred FJ van IJcken, Jan A. N. Verhaar, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Rudi W. Hendriks, Jacques J. M. van Dongen, Anton W. Langerak
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Immunity & Ageing
Subjects:
Aging
B-lymphocyte
BCR repertoire
CLL
Stereotypic BCR
Online Access:http://link.springer.com/article/10.1186/s12979-019-0163-x

Internet

http://link.springer.com/article/10.1186/s12979-019-0163-x

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