TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair

TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair

ObjectiveThe actin-sequestering proteins, thymosin beta-4 (Tβ4) and hypoxia-inducible factor (HIF)-1α, are known to be associated with angiogenesis after myocardial infarction (MI). Herein, we aimed to identify the mechanism of HIF-1α induction by Tβ4 and investigate the effects of bone marrow mesen...

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Bibliographic Details
Main Authors: Shiyuan Tang, Chengming Fan, Chukwuemeka Daniel Iroegbu, Wenwu Zhou, Zhigong Zhang, Ming Wu, Wangping Chen, Xiaoming Wu, Jun Peng, Zhihong Li, Jinfu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
thymosin beta-4
hypoxia-inducible factor-1α
mesenchymal stromal cell
angiogenesis
heart failure
AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.670913/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.670913/full

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