Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.
Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease (AD) amyloid precursor protein (APP). Triplic...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-05-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2873949?pdf=render |