P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells

Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficienc...

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Bibliographic Details
Main Authors: Alwin de Jong, Rob C. M. de Jong, Erna A. Peters, Ramon Arens, J. Wouter Jukema, Margreet R. de Vries, Paul H. A. Quax
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiovascular disease
atherosclerosis
inflammation
PCAF
regulatory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.604821/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2020.604821/full

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