Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

Summary: Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that the transcription factor WT1 forms a major node in the rewired mutation-specific...

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Bibliographic Details
Main Authors: Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J.L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
acute myeloid leukemia
Wilms tumour 1
t(8;21) AML
FLT3-ITD AML
gene regulatory networks
chromatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003247

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http://www.sciencedirect.com/science/article/pii/S2211124721003247

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