Alzheimer disease: crosstalk between the canonical Wnt/beta-catenin pathway and PPARs alpha and gamma

Alzheimer disease: crosstalk between the canonical Wnt/beta-catenin pathway and PPARs alpha and gamma

The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma (mARN and protein) is upregulated. Certain n...

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Bibliographic Details
Main Authors: Alexandre VALLEE, Yves Lecarpentier
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer Disease
Lithium
PPAR alpha
PPAR gamma
Riluzole
Wnt/Beta-Catenin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00459/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00459/full

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