Anti-Proliferative and Apoptosis-Inducing Effects of Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic Ester in Human Breast Tumor MCF-7 Cells

Anti-Proliferative and Apoptosis-Inducing Effects of Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic Ester in Human Breast Tumor MCF-7 Cells

Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic ester (CPT6) is a novel semi-synthetic analog of camptothecin. In a previous report, CPT6 possessed higher cytotoxic activity in vitro towards human breast tumor MCF-7 cells than topotecan. In this study, the antitumor activity of CPT6 on the human breast...

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Bibliographic Details
Main Authors: Chu Chu, Jialin Xu, Dongping Cheng, Xingnuo Li, Shengqiang Tong, Jizong Yan, Qingyong Li
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic ester
MCF-7 cell line
anti-proliferative
apoptosis
Online Access:http://www.mdpi.com/1420-3049/19/4/4941

Internet

http://www.mdpi.com/1420-3049/19/4/4941

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