Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching

Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is a widely used anticonvulsant drug that is currently undergoing clinical evaluation for anticancer therapy due to its anti-angiogenic potential. Endothelial cells (ECs) can transition into mesenchymal cells and this form of EC plasticity...

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Bibliographic Details
Main Authors: Shamini Murugavel, Antoinette Bugyei-Twum, Pratiek N. Matkar, Husain Al-Mubarak, Hao H. Chen, Mohamed Adam, Shubha Jain, Tanya Narang, Rawand M. Abdin, Mohammad Qadura, Kim A. Connelly, Howard Leong-Poi, Krishna K. Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
valproic acid
endothelial cell
endothelial dysfunction
endothelial-to-mesenchymal transition
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00737/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00737/full

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