Ab locks for improving the selectivity and safety of antibody drugs

Abstract Monoclonal antibodies (mAbs) are a major targeted therapy for malignancies, infectious diseases, autoimmune diseases, transplant rejection and chronic inflammatory diseases due to their antigen specificity and longer half-life than conventional drugs. However, long-term systemic antigen neu...

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Bibliographic Details
Main Authors: Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang, Tian-Lu Cheng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Biomedical Science
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12929-020-00652-z