CDKL5 is a brain MeCP2 target gene regulated by DNA methylation

CDKL5 is a brain MeCP2 target gene regulated by DNA methylation

Rett syndrome and its “early-onset seizure” variant are severe neurodevelopmental disorders associated with mutations within the MECP2 and the CDKL5 genes. Antidepressants and drugs of abuse induce the expression of the epigenetic factor MeCP2, thereby influencing chromatin remodeling. We show that...

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Bibliographic Details
Main Authors: Delphine Carouge, Lionel Host, Dominique Aunis, Jean Zwiller, Patrick Anglard
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
Neurodevelopmental disorders
Drug of abuse
Epigenetics
DNA methylation
Chromatin remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000628

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http://www.sciencedirect.com/science/article/pii/S0969996110000628

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