AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

Liver metastasis is the main cause of colorectal cancer (CRC)‐related death. Neutrophil extracellular traps (NETs) play important roles in CRC progression. Deoxyribonuclease I (DNase I) has been shown to alter NET function by cleaving DNA strands comprising the NET backbone. Moreover, DNase I displa...

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Bibliographic Details
Main Authors: Yujia Xia, Jiayi He, Hongji Zhang, Han Wang, George Tetz, Casey A. Maguire, Yu Wang, Amblessed Onuma, Dmitry Genkin, Victor Tetz, Alexey Stepanov, Stanislav Terekhov, Valeria Ukrainskaya, Hai Huang, Allan Tsung
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Molecular Oncology
Subjects:
adeno‐associated virus
Deoxyribonuclease I
metastatic colorectal cancer
neutrophil extracellular traps
Online Access:https://doi.org/10.1002/1878-0261.12787

Internet

https://doi.org/10.1002/1878-0261.12787

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