Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome

Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome

Abstract Background Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric antigen receptor (CAR) engineered T cells. However, current treatment opti...

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Bibliographic Details
Main Authors: Ye Wei, Chong Li, Huifang Bian, Wei Qian, Kairui Jin, Tingting Xu, Xiaomao Guo, Xueguan Lu, Fengtao Su
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Cancer
Subjects:
Cyclin-dependent kinase 7
Super enhancer
Inflammatory genes
Cytokine release syndrome
Macrophages
Chimeric antigen receptor engineered T cells
Online Access:https://doi.org/10.1186/s12943-020-01301-7

Internet

https://doi.org/10.1186/s12943-020-01301-7

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