BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer

BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer

We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deleti...

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Bibliographic Details
Main Authors: Mitrović Olivera, Mićić Mileva, Čokić V., Koko Vesna, Đikić Dragoslava, Budeč Mirela, Vignjević Sanja, Breković Tijana
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2013-01-01
Series:Archives of Biological Sciences
Subjects:
BRCA1
TOP2A
FISH
immunohistochemistry
molecular subtypes of breast cancer
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641302511M.pdf

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http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641302511M.pdf

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