De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

Neuroactive steroids are potent modulators of microglial functions and are capable of counteracting their excessive reactivity. This action has mainly been ascribed to neuroactive steroids released from other sources, as microglia have been defined unable to produce neurosteroids de novo. Unexpected...

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Bibliographic Details
Main Authors: Lorenzo Germelli, Eleonora Da Pozzo, Chiara Giacomelli, Chiara Tremolanti, Laura Marchetti, Christian H. Wetzel, Elisabetta Barresi, Sabrina Taliani, Federico Da Settimo, Claudia Martini, Barbara Costa
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
18 kDa TSPO
human microglial cells
neurosteroidogenesis
neurosteroids
CYP11A1
StAR protein
Online Access:https://www.mdpi.com/1422-0067/22/6/3115

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https://www.mdpi.com/1422-0067/22/6/3115

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