Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.

Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.

BACKGROUND:Chagas disease results from infection with the diploid protozoan parasite Trypanosoma cruzi. T. cruzi is highly genetically diverse, and multiclonal infections in individual hosts are common, but little studied. In this study, we explore T. cruzi infection multiclonality in the context of...

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Bibliographic Details
Main Authors: Martin S Llewellyn, Louisa A Messenger, Alejandro O Luquetti, Lineth Garcia, Faustino Torrico, Suelene B N Tavares, Bachar Cheaib, Nicolas Derome, Marc Delepine, Céline Baulard, Jean-Francois Deleuze, Sascha Sauer, Michael A Miles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4388557?pdf=render

Internet

http://europepmc.org/articles/PMC4388557?pdf=render

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