Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis

Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis

Recombinant matrices have enabled feeder cell-free maintenance cultures of human pluripotent stem cells (hPSCs), with laminin 511-E8 fragment (LM511-E8) being widely used. However, we herein report that hPSCs maintained on LM511-E8 resist differentiating to multipotent hematopoietic progenitor cells...

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Bibliographic Details
Main Authors: Akinori Yuzuriha, Sou Nakamura, Naoshi Sugimoto, Shunsuke Kihara, Masato Nakagawa, Takuya Yamamoto, Kiyotoshi Sekiguchi, Koji Eto
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Stem Cell Research
Subjects:
Hematopoietic cell differentiation
Laminin
Integrin β1
ILK
Canonical Wnt/β-catenin pathway
Pluripotent stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121001331

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http://www.sciencedirect.com/science/article/pii/S1873506121001331

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