Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9 is mainly secreted by the liver, whereas VLDL is...

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Bibliographic Details
Main Authors: Bingxiang Wang, Yishi Shen, Lei Zhai, Xiaodan Xia, Hong-mei Gu, Maggie Wang, Yongfang Zhao, Xiaole Chang, Adekunle Alabi, Sijie Xing, Shijun Deng, Boyan Liu, Guiqing Wang, Shucun Qin, Da-wei Zhang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
apolipoproteins
LDL
lipid metabolism
lipoprotein metabolism
liver
triglyceride
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000730

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http://www.sciencedirect.com/science/article/pii/S0022227521000730

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