Promyelocytic leukemia protein deficiency leads to spontaneous formation of liver tumors in hepatitis C virus transgenic mice

Promyelocytic leukemia protein deficiency leads to spontaneous formation of liver tumors in hepatitis C virus transgenic mice

Abstract Persistent infection with hepatitis C virus (HCV) is a known risk factor for the development of hepatocellular carcinoma (HCC). The lack of the tumor suppressor promyelocytic leukemia protein (PML) in combination with HCV fosters hepatocarcinogenesis via induction of HCC using diethylnitros...

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Bibliographic Details
Main Authors: Katja Straub, Peri Husen, Hideo A. Baba, Martin Trippler, Heiner Wedemeyer, Kerstin Herzer
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Cancer Medicine
Subjects:
hepatitis C virus
hepatocellular carcinoma
liver tumor
promyelocytic leukemia protein
Online Access:https://doi.org/10.1002/cam4.2162

Internet

https://doi.org/10.1002/cam4.2162

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