ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner[S]

ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner[S]

ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM d...

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Bibliographic Details
Main Authors: Yu Zhao, Masato Ishigami, Kohjiro Nagao, Kentaro Hanada, Nozomu Kono, Hiroyuki Arai, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette protein
ATP binding cassette transporter A1
myriosin
cholesterol
high density lipoprotein
(1R,3S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355929

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http://www.sciencedirect.com/science/article/pii/S0022227520355929

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