ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner[S]
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM d...
Main Authors: | Yu Zhao, Masato Ishigami, Kohjiro Nagao, Kentaro Hanada, Nozomu Kono, Hiroyuki Arai, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-03-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520355929 |
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