PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.

We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although increased circulating mitochondrial DNA (mtDNA) has b...

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Bibliographic Details
Main Authors: Marta Bueno, Daniel Zank, Ivette Buendia-Roldán, Kaitlin Fiedler, Brenton G Mays, Diana Alvarez, John Sembrat, Brian Kimball, Jordan K Bullock, James L Martin, Mehdi Nouraie, Brett A Kaufman, Mauricio Rojas, Annie Pardo, Moisés Selman, Ana L Mora
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218003

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https://doi.org/10.1371/journal.pone.0218003

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