PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.

We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although increased circulating mitochondrial DNA (mtDNA) has b...

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Bibliographic Details
Main Authors: Marta Bueno, Daniel Zank, Ivette Buendia-Roldán, Kaitlin Fiedler, Brenton G Mays, Diana Alvarez, John Sembrat, Brian Kimball, Jordan K Bullock, James L Martin, Mehdi Nouraie, Brett A Kaufman, Mauricio Rojas, Annie Pardo, Moisés Selman, Ana L Mora
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218003