Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

Disease-associated loci identified through genome-wide association studies (GWAS) frequently localize to non-coding sequence. We and others have demonstrated strong enrichment of such single nucleotide polymorphisms (SNPs) for expression quantitative trait loci (eQTLs), supporting an important role...

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Bibliographic Details
Main Authors: Damien C Croteau-Chonka, Angela J Rogers, Towfique Raj, Michael J McGeachie, Weiliang Qiu, John P Ziniti, Benjamin J Stubbs, Liming Liang, Fernando D Martinez, Robert C Strunk, Robert F Lemanske, Andrew H Liu, Barbara E Stranger, Vincent J Carey, Benjamin A Raby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608673?pdf=render

Internet

http://europepmc.org/articles/PMC4608673?pdf=render

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