How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]

How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]

Since the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level by in vitro studies. Largely for technical reasons, however, the confirmation of these subpathways in vivo has been elusive. We review...

Full description

Bibliographic Details
Main Authors: Upasna Thapar, Bruce Demple
Format: Article
Language:English
Published: F1000 Research Ltd 2017-03-01
Series:F1000Research
Subjects:
Chemical Biology of the Cell
Control of Gene Expression
Experimental Biophysical Methods
Nuclear Structure & Function
Structure: Replication & Repair
Online Access:https://f1000research.com/articles/6-279/v1
id doaj-685c4e8c2a5d445da8d520e4ff1497d8
record_format Article
spelling doaj-685c4e8c2a5d445da8d520e4ff1497d82020-11-25T03:43:48ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10538.111356How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]Upasna Thapar0Bruce Demple1Department of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, NY, USADepartment of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, NY, USASince the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level by in vitro studies. Largely for technical reasons, however, the confirmation of these subpathways in vivo has been elusive. We review methods that have been used to explore BER in mammalian cells, indicate where there are important knowledge gaps to fill, and suggest a way to address them.https://f1000research.com/articles/6-279/v1Chemical Biology of the CellControl of Gene ExpressionExperimental Biophysical MethodsNuclear Structure & FunctionStructure: Replication & Repair
collection DOAJ
language English
format Article
sources DOAJ
author Upasna Thapar
Bruce Demple
spellingShingle Upasna Thapar
Bruce Demple
How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
F1000Research
Chemical Biology of the Cell
Control of Gene Expression
Experimental Biophysical Methods
Nuclear Structure & Function
Structure: Replication & Repair
author_facet Upasna Thapar
Bruce Demple
author_sort Upasna Thapar
title How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
title_short How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
title_full How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
title_fullStr How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
title_full_unstemmed How are base excision DNA repair pathways deployed in vivo? [version 1; referees: 4 approved]
title_sort how are base excision dna repair pathways deployed in vivo? [version 1; referees: 4 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2017-03-01
description Since the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level by in vitro studies. Largely for technical reasons, however, the confirmation of these subpathways in vivo has been elusive. We review methods that have been used to explore BER in mammalian cells, indicate where there are important knowledge gaps to fill, and suggest a way to address them.
topic Chemical Biology of the Cell
Control of Gene Expression
Experimental Biophysical Methods
Nuclear Structure & Function
Structure: Replication & Repair
url https://f1000research.com/articles/6-279/v1
work_keys_str_mv AT upasnathapar howarebaseexcisiondnarepairpathwaysdeployedinvivoversion1referees4approved
AT brucedemple howarebaseexcisiondnarepairpathwaysdeployedinvivoversion1referees4approved
_version_ 1724518298461143040

Similar Items