Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes. In the attempt to identify new therapeutic strategies for CCA, we studied the antiproliferative activity of a combination...

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Bibliographic Details
Main Authors: Antonella Di Sotto, Silvia Di Giacomo, Elisabetta Rubini, Alberto Macone, Marco Gulli, Caterina Loredana Mammola, Margherita Eufemi, Romina Mancinelli, Gabriela Mazzanti
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
chemoprevention
genoprotective effects
caryophyllane sesquiterpenes
liver cancer
metronomic schedule
GSH depletion
Online Access:https://www.mdpi.com/2073-4409/9/4/858

Internet

https://www.mdpi.com/2073-4409/9/4/858

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