Mammalian <it>NPC1 </it>genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Mammalian <it>NPC1 </it>genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

<p>Abstract</p> <p>Background</p> <p>The <it>NPC1 </it>gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in <it>NPC1 </it>was associate...

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Bibliographic Details
Main Authors: Al-Daghri Nasser M, Cagliani Rachele, Forni Diego, Alokail Majed S, Pozzoli Uberto, Alkharfy Khalid M, Sabico Shaun, Clerici Mario, Sironi Manuela
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Medicine
Subjects:
NPC1
filovirus
natural selection
type 2 diabetes
Online Access:http://www.biomedcentral.com/1741-7015/10/140

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http://www.biomedcentral.com/1741-7015/10/140

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