Proteomic and Transcriptomic Analysis Identify Spliceosome as a Significant Component of the Molecular Machinery in the Pituitary Tumors Derived from <i>POU1F1</i>-and <i>NR5A1</i>-Cell Lineages

Proteomic and Transcriptomic Analysis Identify Spliceosome as a Significant Component of the Molecular Machinery in the Pituitary Tumors Derived from <i>POU1F1</i>-and <i>NR5A1</i>-Cell Lineages

<b>Background:</b> Pituitary adenomas (PA) are the second most common tumor in the central nervous system and have low counts of mutated genes. Splicing occurs in 95% of the coding RNA. There is scarce information about the spliceosome and mRNA-isoforms in PA, and therefore we carried ou...

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Main Authors: Keiko Taniguchi-Ponciano, Eduardo Peña-Martínez, Gloria Silva-Román, Sandra Vela-Patiño, Ana Laura Guzman-Ortiz, Hector Quezada, Erick Gomez-Apo, Laura Chavez-Macias, Sophia Mercado-Medrez, Guadalupe Vargas-Ortega, Ana Laura Espinosa-de-los-Monteros, Baldomero Gonzales-Virla, Aldo Ferreira-Hermosillo, Etual Espinosa-Cardenas, Claudia Ramirez-Renteria, Ernesto Sosa, Blas Lopez-Felix, Gerardo Guinto, Daniel Marrero-Rodríguez, Moises Mercado
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Genes
Subjects:
pituitary adenomas
alternative splicing
molecular markers
mRNA isoforms
Online Access:https://www.mdpi.com/2073-4425/11/12/1422

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https://www.mdpi.com/2073-4425/11/12/1422

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