YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Abstract Background Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened extract of G. biloba, showed anti-inflammatory, neurotrophic, and antioxidant effects. Results...

Full description

Bibliographic Details
Main Authors: Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima, Hyoung-Chun Kim
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Neuroinflammation
Subjects:
Terpene trilactone-strengthened G. biloba
Platelet-activating factor
Peroxisome proliferators-activated receptor γ
Microglia
APPswe/PS1dE9 transgenic mice
Cyclooxygenase-2 knockout mice
Online Access:http://link.springer.com/article/10.1186/s12974-017-0866-x

Internet

http://link.springer.com/article/10.1186/s12974-017-0866-x

Similar Items